Autophagy related 14 protects against liver injury by inhibiting multiple cell death pathways. Kim HG, Huang M, Wang S, Zhang Y, Li K, Liu S, Dong C, Yang X, Cho JH, Chowdhury K, Stein B, Wan J, Dong XC.eGastroenterology. 2025 Oct 13;3(4):e100181. doi: 10.1136/egastro-2025-100181. eCollection 2025.

Steatotic liver disease and cancer: from pathogenesis to therapeutic targets. Yang Z, Liu Z, Liu W, Dong XC.eGastroenterology. 2025 Sep 12;3(3):e100218. doi: 10.1136/egastro-2025-100218. eCollection 2025.

SIRT6 Is a Key Regulator of Pancreatic β-Cell Survival and Function During Aging. Park J, Lokuge SD, Huang M, Wang S, Liu S, Liang J, Katturajan R, Marakovits C, Yang Z, Wan J, Dong XC.Diabetes. 2025 Nov 1;74(11):1976-1991. doi: 10.2337/db25-0116.

The Patatin-Like Phospholipase Domain-Containing 3 148M Variant Exacerbates Alcohol-Induced Liver Injury and Tumorigenesis in Mice. Cho JH, Kim HG, Huang M, Wang S, Liu S, Lu A, McCrocklin K, Zhang Y, Fang Z, Wang J, Liu W, Wan J, Dong XC.Am J Pathol. 2026 Jan;196(1):209-222. doi: 10.1016/j.ajpath.2025.04.014. Epub 2025 May 9.

Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1. Hazari Y, Habbouche L, Garcia Lopez VA, Urra H, Diaz J, Tamburini G, Milani M, Durand S, Aprahamian F, Baxter R, Huang M, Dong XC, Gonzalez-Rojas L, Francisco SJ, Tapia-Dufey I, Vihinen H, Ratziu V, Foufelle F, Hengstler JG, Jokitalo E, Maiers JL, Plate L, Kroemer G, Bailly-Maitre B, Hetz C.Hepatology. 2026 Jan 1;83(1):75-93. doi: 10.1097/HEP.0000000000001335. Epub 2025 Apr 8.

Sirt6 protects retinal ganglion cells and optic nerve from degeneration during aging and glaucoma. Xia F, Shi S, Palacios E, Liu W, Buscho SE, Li J, Huang S, Vizzeri G, Dong XC, Motamedi M, Zhang W, Liu H.Mol Ther. 2024 Jun 5;32(6):1760-1778. doi: 10.1016/j.ymthe.2024.04.030. Epub 2024 Apr 24.

ATG14 plays a critical role in hepatic lipid droplet homeostasis. Huang M, Zhang Y, Park J, Chowdhury K, Xu J, Lu A, Wang L, Zhang W, Ekser B, Yu L, Dong XC.Metabolism. 2023 Nov;148:155693. doi: 10.1016/j.metabol.2023.155693. Epub 2023 Sep 22.

Sirtuin 6-A Key Regulator of Hepatic Lipid Metabolism and Liver Health. Dong XC.Cells. 2023 Feb 19;12(4):663. doi: 10.3390/cells12040663.

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis. Cordova RA, Misra J, Amin PH, Klunk AJ, Damayanti NP, Carlson KR, Elmendorf AJ, Kim HG, Mirek ET, Elzey BD, Miller MJ, Dong XC, Cheng L, Anthony TG, Pili R, Wek RC, Staschke KA.Elife. 2022 Sep 15;11:e81083. doi: 10.7554/eLife.81083.

Sirtuin 6 protects against hepatic fibrogenesis by suppressing the YAP and TAZ function. Chowdhury K, Huang M, Kim HG, Dong XC.FASEB J. 2022 Oct;36(10):e22529. doi: 10.1096/fj.202200522R.

Signal Transduction and Molecular Regulation in Fatty Liver Disease. Dong XC, Chowdhury K, Huang M, Kim HG.Antioxid Redox Signal. 2021 Sep 20;35(9):689-717. doi: 10.1089/ars.2021.0076. Epub 2021 Jun 3.

Aberrant gene expression induced by a high fat diet is linked to H3K9 acetylation in the promoter-proximal region. Morral N, Liu S, Conteh AM, Chu X, Wang Y, Dong XC, Liu Y, Linnemann AK, Wan J. Biochim Biophys Acta Gene Regul Mech. 2021 Mar;1864(3):194691. [PMID: 33556624]

Sirt1 coordinates with ERα to regulate autophagy and adiposity. Tao Z, Shi L, Parke J, Zheng L, Gu W, Dong XC, Liu D, Wang, Z, Olumi AF, Cheng Z. Cell Death Discov. 2021 Mar 15;7(1):53. [PMID: 33723227]

Sestrin proteins protect against lipotoxicity-induced oxidative stress in the liver via suppression of C-Jun N-terminal kinases. Fang Z, Kim HG, Huang M, Chowdhury K, Li MO, Liangpunsakul S, Dong XC. Cell Mol Gastroenterol Hepatol. 2021 May 4:S2352-345X(21)00086-2. [PMID: 33962074]

Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. Misra J, Holmes MJ, Mirek ET, Langevin M, Kim HG, Carlson KR, Watford M, Dong XC, Anthony TG, Wek, RC. Nucleic Acids Res. 2021 Jun 4;49(10):5726-5742. [PMID: 34023907]

Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway. Xu L, Zhang X, Xin Y, Ma J, Yang C, Zhang X, Hou G, Dong XC, Sun Z, Xiong X, Cao X. Cell Death Dis. 2021 Jul 15;12(7):710. [PMID: 34267188]

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells. Zhong X, Huang M, Kim HG, Zhang Y, Chowdhury K, Cai W, Saxena R, Schwabe RF, Liangpunsakul S, Dong XC. Cell Mol Gastroenterol Hepatol. 2020 Apr 17:S2352-345X(20)30049-7. doi: 10.1016/j.jcmgh.2020.04.005. Online ahead of print. [PMID: 32305562]

Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping. Liu Z, Zhang Y, Graham S, Wang X, Cai D, Huang M, Pique-Regi R, Dong XC, Chen YE, Willer C, Liu W. J Hepatol. 2020 Mar 10:S0168-8278(20)30164-1. doi: 10.1016/j.jhep.2020.03.006. Online ahead of print. [PMID: 32165250]

PNPLA3-A Potential Therapeutic Target for Personalized Treatment of Chronic Liver Disease. Dong XC. Front Med (Lausanne). 2019 Dec 17;6:304. doi: 10.3389/fmed.2019.00304. eCollection 2019. [PMID: 31921875]

Sestrin 3 Protects Against Diet-Induced Nonalcoholic Steatohepatitis in Mice Through Suppression of Transforming Growth Factor β Signal Transduction. Huang M, Kim HG, Zhong X, Dong C, Zhang B, Fang Z, Zhang Y, Lu X, Saxena R, Liu Y, Zhang C, Liangpunsakul S, Dong XC. Hepatology. 2020 Jan;71(1):76-92. doi: 10.1002/hep.30820. Epub 2019 Sep 27. [PMID: 31215672]

SliceIt: A genome-wide resource and visualization tool to design CRISPR/Cas9 screens for editing protein-RNA interaction sites in the human genome. Vemuri S, Srivastava R, Mir Q, Hashemikhabir S, Dong XC, Janga SC. Methods. 2020 Jun 1;178:104-113. doi: 10.1016/j.ymeth.2019.09.004. Epub 2019 Sep 5. [PMID: 31494246]

Sesn3 deficiency promotes carcinogen-induced hepatocellular carcinoma via regulation of the hedgehog pathway. Liu Y, Kim HG, Dong E, Dong C, Huang M, Liu Y, Liangpunsakul S, Dong XC. Biochim Biophys Acta Mol Basis Dis. 2019 Oct 1;1865(10):2685-2693. doi: 10.1016/j.bbadis.2019.07.011. Epub 2019 Jul 24. [PMID: 31351129]

The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice. Kim HG, Huang M, Xin Y, Zhang Y, Zhang X, Wang G, Liu S, Wan J, Ahmadi AR, Sun Z, Liangpunsakul S, Xiong X, Dong XC. J Hepatol. 2019 Nov;71(5):960-969. doi: 10.1016/j.jhep.2019.06.019. Epub 2019 Jul 8. [PMID: 31295533]

Inactivating hepatic follistatin alleviates hyperglycemia. Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF. Nat Med. 2018 Jul;24(7):1058-1069. doi: 10.1038/s41591-018-0048-0. Epub 2018 Jun 4. [PMID: 29867232]

Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice. Xiong X, Zhang C, Zhang Y, Fan R, Qian X, Dong XC. J Endocrinol. 2017 Jun;233(3):307-314. doi: 10.1530/JOE-17-0033. Epub 2017 Apr 6. [PMID: 28385723]

FOXO transcription factors protect against the diet-induced fatty liver disease. Pan X, Zhang Y, Kim HG, Liangpunsakul S, Dong XC. Sci Rep. 2017 Mar 16;7:44597. doi: 10.1038/srep44597. [PMID: 28300161]

SIRT6 protects against palmitate-induced pancreatic β-cell dysfunction and apoptosis. Xiong X, Sun X, Wang Q, Qian X, Zhang Y, Pan X, Dong XC. J Endocrinol. 2016 Nov;231(2):159-165. doi: 10.1530/JOE-16-0317. Epub 2016 Sep 6. [PMID: 27601447]

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells. Xiong X, Wang G, Tao R, Wu P, Kono T, Li K, Ding WX, Tong X, Tersey SA, Harris RA, Mirmira RG, Evans-Molina C, Dong XC. Diabetologia. 2016 Jan;59(1):151-160. doi: 10.1007/s00125-015-3778-2. [PMID: 26471901]

Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling. Tao R, Xiong X, Liangpunsakul S, Dong XC. Diabetes. 2015 Apr;64(4):1211-23. doi: 10.2337/db14-0539. Epub 2014 Nov 5. [PMID: 25377878]