Aberrant gene expression induced by a high fat diet is linked to H3K9 acetylation in the promoter-proximal region. Morral N, Liu S, Conteh AM, Chu X, Wang Y, Dong XC, Liu Y, Linnemann AK, Wan J. Biochim Biophys Acta Gene Regul Mech. 2021 Mar;1864(3):194691. [PMID: 33556624]

Sirt1 coordinates with ERα to regulate autophagy and adiposity. Tao Z, Shi L, Parke J, Zheng L, Gu W, Dong XC, Liu D, Wang, Z, Olumi AF, Cheng Z. Cell Death Discov. 2021 Mar 15;7(1):53. [PMID: 33723227]

Sestrin proteins protect against lipotoxicity-induced oxidative stress in the liver via suppression of C-Jun N-terminal kinases. Fang Z, Kim HG, Huang M, Chowdhury K, Li MO, Liangpunsakul S, Dong XC. Cell Mol Gastroenterol Hepatol. 2021 May 4:S2352-345X(21)00086-2. [PMID: 33962074]

Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. Misra J, Holmes MJ, Mirek ET, Langevin M, Kim HG, Carlson KR, Watford M, Dong XC, Anthony TG, Wek, RC. Nucleic Acids Res. 2021 Jun 4;49(10):5726-5742. [PMID: 34023907]

Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway. Xu L, Zhang X, Xin Y, Ma J, Yang C, Zhang X, Hou G, Dong XC, Sun Z, Xiong X, Cao X. Cell Death Dis. 2021 Jul 15;12(7):710. [PMID: 34267188]

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells. Zhong X, Huang M, Kim HG, Zhang Y, Chowdhury K, Cai W, Saxena R, Schwabe RF, Liangpunsakul S, Dong XC. Cell Mol Gastroenterol Hepatol. 2020 Apr 17:S2352-345X(20)30049-7. doi: 10.1016/j.jcmgh.2020.04.005. Online ahead of print. [PMID: 32305562]

Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping. Liu Z, Zhang Y, Graham S, Wang X, Cai D, Huang M, Pique-Regi R, Dong XC, Chen YE, Willer C, Liu W. J Hepatol. 2020 Mar 10:S0168-8278(20)30164-1. doi: 10.1016/j.jhep.2020.03.006. Online ahead of print. [PMID: 32165250]

PNPLA3-A Potential Therapeutic Target for Personalized Treatment of Chronic Liver Disease. Dong XC. Front Med (Lausanne). 2019 Dec 17;6:304. doi: 10.3389/fmed.2019.00304. eCollection 2019. [PMID: 31921875]

Sestrin 3 Protects Against Diet-Induced Nonalcoholic Steatohepatitis in Mice Through Suppression of Transforming Growth Factor β Signal Transduction. Huang M, Kim HG, Zhong X, Dong C, Zhang B, Fang Z, Zhang Y, Lu X, Saxena R, Liu Y, Zhang C, Liangpunsakul S, Dong XC. Hepatology. 2020 Jan;71(1):76-92. doi: 10.1002/hep.30820. Epub 2019 Sep 27. [PMID: 31215672]

SliceIt: A genome-wide resource and visualization tool to design CRISPR/Cas9 screens for editing protein-RNA interaction sites in the human genome. Vemuri S, Srivastava R, Mir Q, Hashemikhabir S, Dong XC, Janga SC. Methods. 2020 Jun 1;178:104-113. doi: 10.1016/j.ymeth.2019.09.004. Epub 2019 Sep 5. [PMID: 31494246]

Sesn3 deficiency promotes carcinogen-induced hepatocellular carcinoma via regulation of the hedgehog pathway. Liu Y, Kim HG, Dong E, Dong C, Huang M, Liu Y, Liangpunsakul S, Dong XC. Biochim Biophys Acta Mol Basis Dis. 2019 Oct 1;1865(10):2685-2693. doi: 10.1016/j.bbadis.2019.07.011. Epub 2019 Jul 24. [PMID: 31351129]

The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice. Kim HG, Huang M, Xin Y, Zhang Y, Zhang X, Wang G, Liu S, Wan J, Ahmadi AR, Sun Z, Liangpunsakul S, Xiong X, Dong XC. J Hepatol. 2019 Nov;71(5):960-969. doi: 10.1016/j.jhep.2019.06.019. Epub 2019 Jul 8. [PMID: 31295533]

Inactivating hepatic follistatin alleviates hyperglycemia. Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF. Nat Med. 2018 Jul;24(7):1058-1069. doi: 10.1038/s41591-018-0048-0. Epub 2018 Jun 4. [PMID: 29867232]

Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice. Xiong X, Zhang C, Zhang Y, Fan R, Qian X, Dong XC. J Endocrinol. 2017 Jun;233(3):307-314. doi: 10.1530/JOE-17-0033. Epub 2017 Apr 6. [PMID: 28385723]

FOXO transcription factors protect against the diet-induced fatty liver disease. Pan X, Zhang Y, Kim HG, Liangpunsakul S, Dong XC. Sci Rep. 2017 Mar 16;7:44597. doi: 10.1038/srep44597. [PMID: 28300161]

SIRT6 protects against palmitate-induced pancreatic β-cell dysfunction and apoptosis. Xiong X, Sun X, Wang Q, Qian X, Zhang Y, Pan X, Dong XC. J Endocrinol. 2016 Nov;231(2):159-165. doi: 10.1530/JOE-16-0317. Epub 2016 Sep 6. [PMID: 27601447]

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells. Xiong X, Wang G, Tao R, Wu P, Kono T, Li K, Ding WX, Tong X, Tersey SA, Harris RA, Mirmira RG, Evans-Molina C, Dong XC. Diabetologia. 2016 Jan;59(1):151-160. doi: 10.1007/s00125-015-3778-2. [PMID: 26471901]

Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling. Tao R, Xiong X, Liangpunsakul S, Dong XC. Diabetes. 2015 Apr;64(4):1211-23. doi: 10.2337/db14-0539. Epub 2014 Nov 5. [PMID: 25377878]